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Benzodiazepine respiratory depressant consequences are more really serious in individuals with critical Serious obstructive airways illness .
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Moguća je pojava pospanosti, smanjenja psihomotornih performansi i slabljenje pamćenja. Stoga se preporučuje primena benzodiazepina koji se ne metabolišu oksidativnim metaboličkim putevima.
Diazepam se uglavnom metaboliše do farmakološki aktivnih metabolita: N-demetildiazepama, temazepama i oksazepama. Oksidativni metabolizam diazepama posredovan je CYP3A4 i CYP2C19 izoenzimima. Oksazepam i temazepam se dalje konjuguju do glukuronske kiseline.
Delayed elimination has also been described for the Energetic metabolite desmethyldiazepam . Benzodiazepines are generally implicated in hepatic encephalopathy . Increases in 50 percent-life have also been documented in hepatic fibrosis As well as in the two acute and Serious hepatitis .
Istovremena primena sa rifampicinom značajno snižava koncentraciju diazepama, što smanjuje njegov efekat. Potrebno je izbegavati istovremenu primenu rifampicina i diazepama.
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